STUDIES / PILLAR 03

Every kind
of trial — across
every phase.

From pre-launch confirmatory studies to post-approval surveillance and digital-therapeutic Erprobungsstudien. Five families of study, one team that has run them all.

One product. A lifecycle
of evidence.

A therapy doesn't stop generating questions when it gets approved. We run the studies that answer them — at every stage.

Pre-Launch
Confirmatory, registration
Erprobungsstudien
§137e, DiGA, ABD
Post-Launch
Phase IV, label expansion
Vigilance
PASS, safety surveillance
Real-World
Registry, evidence syntheses
STUDY TYPE 01

Pre-Launch
Confirmatory trials.

Phase II/III studies designed to support a regulatory filing. Run with adaptive design, integrated biostatistics, and the regulatory team in the room from week one.

80+Trials Run
30+Countries
Phase II–IIISweet spot
EMAFDABfArMADAPTIVECTIS
STUDY TYPE 02

Post-Launch &
Phase IV.

Label-expansion, long-term safety, effectiveness in routine care. Built to answer the questions a regulator will ask next year, not last.

40+Studies
~5yTypical horizon
Open-labelMostly
PHASE IVLABEL EXPANSIONLONG-TERMEFFECTIVENESS
STUDY TYPE 03

Pharmaco-
vigilance studies.

PASS, PAES, and signal-detection studies. Run by a PV team that authors PSURs, not just deliverables. EudraVigilance and FDA gateways included.

24/7ICSR cover
PASS+ PAES
EU-QPPVIn-house
PSURDSUREUDRAVIGILANCESIGNAL DETECTION
STUDY TYPE 04

Erprobungs-
studien (§137e).

Method-evaluation studies for innovative procedures, run under the German G-BA framework. We have walked this path more often than most.

§137eSGB V
G-BAAligned
12+Methods
METHOD EVALG-BASGB VHEALTH ECON
STUDY TYPE 05

Anwendungsbegleitende Datenerhebung — ABD & DiGA studies.

For digital therapeutics and orphan-drug populations, evidence is built differently. We run §35a/§35c ABD studies for AMNOG dossiers and DiGA evaluations for the BfArM directory — combining clinical, real-world and patient-reported endpoints with the agility a digital product cycle demands.

BfArMDiGA registry
AMNOG§35a / §35c
PRO + RWEEndpoint mix
~6–18mTypical horizon
DIGAABDAMNOGRWEPROsFAST-DIGITAL

A few recent studies
we've run.

CodeTherapeutic AreaPhaseSites · Subj.SectorStatus
CSG-241Cardiovascular · HFIII42 · 1,840PharmaLIVE
CSG-238Oncology · NSCLCII18 · 220BiotechLIVE
CSG-235Digital · Type 2 DiabetesDiGA12 · 480DiGALOCK
CSG-232Med Device · Cardiac Mon.§137e22 · 600Med TechLIVE
CSG-227Neurology · MSIV56 · 2,400PharmaDONE
CSG-220Rare Disease · ABDABD8 · 130BiotechDONE

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